Perspectives on Synthetic Materials to Guide Tissue Regeneration for Osteochondral Defect Repair
نویسندگان
چکیده
منابع مشابه
Biomimetic biphasic scaffolds for osteochondral defect repair
The osteochondral defects caused by vigorous trauma or physical disease are difficult to be managed. Tissue engineering provides a possible option to regenerate the damaged osteochondral tissues. For osteochondral reconstruction, one intact scaffold should be considered to support the regeneration of both cartilage and subchondral bone. Therefore, the biphasic scaffolds with the mimic structure...
متن کاملPorous tantalum biocomposites for osteochondral defect repair
OBJECTIVES We sought to determine if a durable bilayer implant composed of trabecular metal with autologous periosteum on top would be suitable to reconstitute large osteochondral defects. This design would allow for secure implant fixation, subsequent integration and remodeling. MATERIALS AND METHODS Adult sheep were randomly assigned to one of three groups (n = 8/group): 1. trabecular metal...
متن کاملAutologous tissue transplantations for osteochondral repair.
Articular cartilage forms the articulating surface of synovial joints. Along with the synovial fluid it facilitates near frictionless movement in healthy joints. Injuries to articular cartilage in the knee are frequent and can lead to severe osteoarthritis, which is expected to affect 25% of the adult population by 2030. Hyaline cartilage does not regenerate spontaneously when injured and the c...
متن کاملAutologous Dual-Tissue Transplantation for Osteochondral Repair
BACKGROUND Numerous treatment methods for osteochondral repair have been implemented, including auto- and allogeneic osteochondral transplantations, combined bone and chondrocyte transplantations, and synthetic implants, but no gold standard treatment has been established. We present preliminary data on a combined autologous bone and cartilage chips: autologous dual-tissue transplantation (ADTT...
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Controlling structural organization and signaling motif display is of great importance to design the functional tissue regenerating materials. Synthetic phage, genetically engineered M13 bacteriophage has been recently introduced as novel tissue regeneration materials to display a high density of cell-signaling peptides on their major coat proteins for tissue regeneration purposes. Structural a...
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ژورنال
عنوان ژورنال: ACS Biomaterials Science & Engineering
سال: 2020
ISSN: 2373-9878,2373-9878
DOI: 10.1021/acsbiomaterials.0c00753